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10.1016/j.abb.2012.02.019 Arch

This article delineates the mechanistic interplay in PD between S pathology, sirtuin dysregulation, and impaired insulin signaling, illustrating how systemic metabolic dysfunction may contribute to the progression of neurodegeneration

An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins

This overstimulation results in increased intracellular calcium levels, leading to neuronal injury and apoptosis ( Postmortem examination of patients with chronic epilepsy reveals a noticeable atrophy of cerebellar Purkinje cells (Yardmoglu et al., 2007)