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Transforming growth factor-1 (TGF-1) can induce the EMT phenotype in melanoma cells and upregulate the levels of GPX4 and SLC7A11, while gambogenic acid, a xanthone derived from traditional Chinese medicine Gamboge, can promote ferroptosis by inhibiting the SLC7A11/GPX4 pathway in melanoma cells stimulated by TGF-1

This promotes the transcription of some of these genes and a de novo synthesis of the corresponding protective proteins, which in the liver, include glutathione-S-transferases (GSTs) [20]

For ZnONP treatments, a strong correlation was observed between callus biomass and pigment contents

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