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It is characterized by abnormal metabolism of the three major nutrients and suppression of mitochondrial oxidative phosphorylation (OXPHOS), which contributes to the onset and development of DKD

Marini F, Hall B, Dembinski J, Studeny M, Sasser AK, Andreeff M

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GCL is composed of a catalytic (GCLC, Mr ~73 kDa) and a modifier (GCLM, Mr ~31 kDa) subunit [32] (summarized in Fig

Another reason is the ability of phenanthriplatin to inhibit transcription, the process by which cells convert DNA to RNA in the first step of gene expression