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Mianserin, a tetracyclic antidepressant, has been shown to inhibit tumor growth in SW480 cells in vitro and in vivo through ASCT2 inhibition ( 3.3 Glutamate dehydrogenase (GLUD/GDH) inhibitors Glutamine is enzymatically converted to glutamate by glutaminase, and further conversion of glutamate to -KG is facilitated by GLUD through oxidative deamination (Yoo et al., 2020)

The thiolase activity of MTP (LCKAT) can be measured by using 3-ketopalmitoyl-CoA as substrate [5]

Key terms explained: Oxidative stress Oxidative stress is an imbalance of free radicals and antioxidants in the body

Carnitines participate in the metabolism of branch-chain amino acids and stabilise cellular membranes (Shalev et al

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