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Compare that to direct hormone replacement, which tops off levels from the outside and can sometimes suppress the glands own output over time

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[26] [27] [28] Among other problems, weakened immunity, reduced fertility and interruption of blood circulation in women may occur

These statements have not been evaluated by the FDA.

The power to detect differences between the study groups is larger than what is projected here as we will measure most of the outcomes more than once and also use these repeated measurements in the same analyses, adjusting for interdependence within a child using mixed effects models, generalised estimating equations or other appropriate methods