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KGN cells (1x103 cells/well) were seeded into a 96-well plate and cultured at 37C for 24 h

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To compensate for impaired phosphorus excretion, bone tissue secretes excessive FGF23, and persistently elevated FGF23 further inhibits renal 1-hydroxylase activity, reduces the synthesis of active vitamin D (1,25(OH) 2 D3), and exacerbates calcium and phosphorus metabolic disorders and bone remodeling imbalance

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Concurrently, Ipamorelin improves nitrogen balance, decreasing catabolic markers, and increasing pituitary and GH mRNA expression, suggesting a synergistic anabolic effect on muscle tissues