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Therefore, focusing on mechanisms contributing to cognitive decline in aging and identifying solutions to improve or reverse ACD will (a) have benefits for improving cognitive health in older adults, and (b) could identify potentially viable mechanistic clues for understanding and combating AD and dementia, especially because both aging and AD share several common associations

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333 Tryptophan catabolism was found to contribute to the escape of the immune response through accumulated catabolites, creating an immunosuppressive microenvironment in tumors and lymph nodes, with the catabolites binding to and activating AhR