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"And it's not because of any magic it's because these are natural substances that our bodies make and are familiar with, so that's what gives them this incredible safety profile." The FDA, however, has publicly stated that there is not enough evidence from human clinical trials on the safety or efficacy of these drugs

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Ntnen R, Gaillard AWK, Mantysalo S (1978)

Second, redness can be harder to see on deeper skin tones, so rosacea and vascular redness are often underrecognized in patients with skin of color, and they may show up more as warmth, sensitivity, or a dusky flush than as bright red