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[2] Amphetamine is eliminated via the kidneys, with 3040% of the drug being excreted unchanged at normal urinary pH

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Hao D, Han G, Sinjab A, Gomez-Bolanos LI, Lazcano R, Serrano A, Hernandez SD, Dai E, Cao X, Hu J, Dang M, Wang R, Chu Y, Song X, Zhang J, Parra ER, Wargo JA, Swisher SG , Cascone T, Sepesi B, Futreal AP, Li M, Dubinett SM, Fujimoto J, Solis Soto LM, Wistuba II, Stevenson CS, Spira A, Shalapour S, Kadara H, Wang L

This hypothesis is consistent with our results showing that curcumin binds to several enzymes functioning in the ROS metabolic pathway and regulating intracellular ROS levels, which trigger p53-dependent and -independent checkpoint pathways, resulting in apoptosis or senescence 23,24,25,26,27

Later, the Modified CTSI was developed by incorporating extrapancreatic complications to further enhance the accuracy of severity evaluation