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In a study, taking a supplement of 2540 g of lysine monohydrochloride over three to five days was found to show no major side effects

ViswanathanVKumpatlaSAravindalochananVRajanRChinnasamyCSrinivasanRet al

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Du X, Matsumura T, Edelstein D, Rossetti L, Zsengellr Z, Szab C, Brownlee M (2003) Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells