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Further studies are required to clarify the role of AMs in the microenvironment of COPD lungs based on the polarization tendencies and functional states at different disease stages, as well as the specific molecular mechanisms involved in these mechanisms to participate in the disease, so as to provide clear directions for macrophage-targeted COPD treatment

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The PCR cycles were set as follows: at 95 C for 15 min, 40 cycles at 94 C for 30 s, 62 C for 30 s and at last 72 C for 1 min per kb

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