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10.1002/phar.1890 137 FournierE.LevequeM.RuizP.RatelJ.DurifC.ChalanconS.et al

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These enzymes, as well as the ATP synthase, are sensitive to the intramitochondrial calcium concentration that increases when cardiac function is challenged since the rate and amplitude of cytosolic calcium transient increases under sympathetic stimulation [34,35,36]

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18,19,20 It may therefore act as a potent inhibitor of T cell activation and in turn affect in the ACPA production