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Indeed, SLC7A11 expression can be potently induced upon deprivation of various amino acids, including cystine, and amino acid deprivation-induced SLC7A11 expression is largely mediated by ATF4 (Sato et al., 2004)

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Een molecule met een extra elektron wordt als onstabiel beschouwd

Researchers combined oncolytic adenovirus (OAd) expressing TNF- and IL-2 with CAR-T and found that it can promote M1 polarization of tumor associated macrophages and increase DC cell maturation, thereby significantly enhancing CAR-T infiltration and anti-tumor effects ( in vitro , thereby enhancing the tumoricidal activity of the combined treatment ( in vivo application of this method may be restricted to immunothermal tumors, as OV cannot enhance infiltration if HER2-CAR-T cells do not first infiltrate the tumor to deposit OV