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2005;5, article 32 doi: 10.1186/1471-2261-5-32

Symptoms of Acanthosis Nigricans Common symptoms include: Dark brown or black patches Thickened skin texture Velvety appearance Skin tags in affected areas Mild itching or odor in some cases These symptoms are usually visible around the neck and underarms , which can affect a persons confidence

Inclusion and ethics statement All co-authors on this study have met the criteria for authorship outlined by Nature Portfolio journals, and the roles and responsibilities of each author were agreed among researchers

Furanodienone down-regulated ER protein and mRNA expression levels without effect to ER expression

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