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1 Introduction Interstitial lung disease (ILD) is a group of common heterogeneous lung diseases characterized by inflammation and fibrosis of lung tissue, which is usually progressive and fatal ( Proteomics is a relatively mature omics field that refers to the study of protein expression, quantification, localization, function, changes in molecular form, posttranslational modification, conformation, chemical modification, and proteinprotein interactions at specific times and under specific conditions ( Table 1 ), in addition to the functions of several important proteins and their correlation with CTD-ILD ( Table 2 ), to provide references for future basic research or clinical application of CTD-ILD