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Results Disorder propensity of Human proIGF-1s We used the D 2 P 2 platform ( and limited proteolysis to predict intrinsically disordered regions of human proIGF-1Ea (ENSP00000416811), proIGF-1Eb (ENSP00000302665) and proIGF-1Ec (ENSP00000376638) 21,22 (Fig

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These include 1) congenital pernicious anaemia, where there is a genetic defect in IF synthesis, leading to B12 malabsorption, 2) Imerslund-Grsbeck Syndrome (IGS) caused by mutations in genes encoding cubulin and amnionless , 3) inherited HC or TCII deficiencies, and 4) intracellular cobalamin defects (CblA-CblG defects)

Thus, in assessing the impact of our proposals, we rely on qualitative evidence of, and experiences with, the use of the public HPT data and feedback from consumers of the MRFs, as well as our own experiences reviewing the MRFs

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