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10.1038/sj.onc.1204054 208 TannerE

Before APAP challenge, IL-1ra KO mice exhibited reduced mRNA expression of these enzymes, compared with WT mice (Figure 2)

3.1.1.2 Anti-inflammatory effects Polyphenolic compounds exert anti-inflammatory effects by negatively regulating inflammatory pathways, especially their regulation of the key NF-B transcription factor (TF) (97, 98)