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Upon bacterial infection, WRS is secreted by the monocytes, and directly binds to macrophages via a toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) complex, inducing phagocytosis and chemokine production ( in vitro and in vivo (Lee et al., 2019)

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Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death

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Kindlin-2 mediates mechanical activation of cardiac myofibroblasts