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Reduction of proinflammatory effector functions through remodeling of fatty acid metabolism in CD8+ T cells from rheumatoid arthritis patients

Published online by Cambridge University Press: 06 March 2023 Abstract Definition of IF regimens Assessment of bone health and fragility Search strategy Studies affecting the effects of intermittent fasting on bone health Mechanistic perspectives Components of energy balance and weight loss Changes in body composition Endocrine factors Changes in dietary factors Circadian biology Changes in gut microbiome References Abstract Intermittent fasting (IF) is a promising strategy for weight loss and improving metabolic health, but its effects on bone health are less clear

This hyperestrogenic state is frequently accompanied by the downregulation of androgen receptor (AR) expression, causing a severe imbalance in the estrogen/androgen receptor (ER/AR) ratio (103, 105), which subsequently disrupts Sertoli cell function and ultimately inhibits sperm development and capacitation (104)