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Although IKK and IKK have contain similar structural domains and possesses 70% homology, the kinase activity of IKK towards IB is 20-50-fold higher than that of IKK [37], therefore, IKK have a higher status in activation of NF-B [38]

[395] observed that RA had an important anti-inflammatory activity in the gut through cytoprotection, mucosal barrier maintenance, and modulation of antioxidant and immunomodulatory systems

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