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In addition, compared to controls, CartIR / mice showed an increase in the number of PCNA-positive chondrocytes in the proliferating zone (Figure 2k and 2l) and a reduction in size of hypertrophic chondrocytes (Figure 2m and 2n)

Exposure of astrocytes to extracellular L-lactate and selective HCA1 agonists, 3Cl-5OH-BA 626 or Compound 2 627 , triggers responses similar to those mediated by -adrenoceptors 628,629,630 , namely an increase in cAMP, cAMP-dependent PKA activity and L-lactate production

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