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both arteries are prone to develop atherosclerotic lesions in ApoE -/- mice

indicated that preoperative treatment with melatonin (10 mg/day, P.O for 30 days) notably raised Nrf2 levels in peripheral blood mononuclear cells of patients undergoing coronary artery bypass grafting (CABG) [208]

Chaves-Filho et al., 2024

3.5 Adverse effects and precautions S-methylmethionine is rapidly absorbed, accumulated in the liver and kidneys, and actively assimilated by the organisms of rats and man