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So statements that topical AHK-Cu is "well tolerated" rest on the copper-peptide class generally much of it built on GHK-Cu (Pickart & Margolina 2018, PMID 29986520) and on community use, rather than on dedicated AHK-Cu safety study

Do not wait until deficiency develops

For higher doses like 8mg, you would need to switch to a higher concentration or use a 20mg vial instead

Reasonable approaches include: Regular blood work every 3-6 months checking metabolic markers, liver function, kidney function, and lipid profiles

Brushing your teeth twice a day and flossing at least once a day helps to maintain your mouth and teeth in good condition