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Risk of Life-Threatening Respiratory Depression and Concomitant Use of Benzodiazepines or Other CNS Depressants with Buprenorphine: Buprenorphine has been associated with life-threatening respiratory depression, overdose, and death, particularly when misused by self-injection or with concomitant use of benzodiazepines or other CNS depressants (e.g., alcohol, nonbenzodiazepine sedative/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids [gabapentin or pregabalin], and other opioids)

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10.1016/j.phymed.2021.153604 33 FengM

B12 excretion in man: an isotope study

There is still limited understanding, awareness, support and integrated care, but one organisation is working to change that