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The above analyses show that BaP may induce a decrease in DNA methylation level accompanied by abnormal methylation patterns of some certain genes (Table 1), and the hypermethylation of tumor suppressor genes by Bap contributes to the occurrence and development of cancer

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[71] [72] [73] Recent epidemiological findings support the process of mitohormesis, but a 2007 meta-analysis finds that in studies with a low risk of bias (randomization, blinding, follow-up), some popular antioxidant supplements (vitamin A, beta carotene, and vitamin E) may increase mortality risk (although studies more prone to bias reported the reverse)

10.3390/medsci6020035 164

Whilst anaemia typically resolves with B12 replacement, neurological damage may be permanent if deficiency remains untreated for extended periods