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J Clin Invest 49(5):952967 Salman HA, Yaakop AS, Aladaileh S, Mustafa M, Gharaibeh M, Kahar UM (2023) Inhibitory effects of Ephedra alte on IL-6, hybrid TLR4, TNF-, IL-1, and extracted TLR4 receptors: in silico molecular docking

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Collect data before and after you make the treatment change

Importantly, after 3 days of intratracheal administration of BUD, LNPs, and BUD-LNPs, the levels of ALT, AST, AKP, BUN, CRE and UA showed no significant differences compared to the control group, indicating that intratracheal administration of BUD-LNPs (contained BUD 0.5 mg/kg) did not cause significant hepatotoxicity and nephrotoxicity (Figure 8bg)

This is particularly relevant given changing groundwater scenarios in many parts of Asia induced by anthropogenic climate change (Shah 2019) which can increase exposure to As toxicity across local, regional and transboundary scales (e.g