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Endosomes release Fe 2+ into the cytoplasmic labile iron pool (LIP), which requires DMT1/Solute Carrier Family 11 Member 2 (SLC11A2) regulation (Zhou et al., 2020) (Figure 3)

Ferroptosis is characterized morphologically by decreased mitochondrial volume, denser mitochondrial bilayer membranes, and often diminished or absent mitochondrial cristae yet with an intact cell membrane, normal-sized nucleus, and no chromatin condensation ( Figure 1 Ferroptosis inducers are categorized into four groups

Brain function may be negatively impacted for some time after disturbances during these time-specific events

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The PTP1B protein is a non-receptor protein tyrosine phosphatase that plays a negative regulatory role in several intracellular signaling pathways, including insulin and leptin signaling