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Consistent with this notion, under conditions of cysteine starvation, the GSH-catabolizing enzyme CHAC1 mobilizes cysteine to sustain mitochondrial Fe-S cluster biogenesis and respiratory function

Lipid-poor apoA-I and mature HDL both contribute to removing cholesterol from macrophages and prevent foam cell formation (Figure 2)

During this reaction, glutathione is converted into oxidized disulfide glutathione (GSSG), which is recycled back to two molecules of glutathione by GSSG reductase at the expense of NADPH/H+, thus forming what is known a redox cycle (Fig

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