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The production of GPX4 and other selenoproteins is highly dependent on SEPHS2, and SEPHS2 has been shown to be a potential target for cancer therapy because of its important role in cancer cell survival

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23 : 127133 Maeda H, Segawa T, Kamoto T, Yoshida H, Kakizuka A, Ogawa O and Kakehi Y (2000) Rapid detection of candidate metastatic foci in the orthotopic inoculation model of androgen-sensitive prostate cancer cells introduced with green fluorescent protein