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The pigmentation is worsened by gingivitis, which increases vascular permeability and allows the heavy metals access to the soft tissues.51 Melanin re-pigmentation is related to after surgical inury

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Each year, an estimated 18.1 million new cases of cancer and 9.6 million cancer deaths occur globally (153)

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Some patients with severe forms of the disease lose all of their scalp hair, eyelashes, eyebrows, and all the rest of their body hair as well, a condition known as alopecia universalis