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Fumarate itself is a Michael acceptor, and the covalent attachment to protein cysteines corresponds to the post-translational modification known as succination [142] and fumarate has been recently demonstrated to yield a glutathione thioether in in vitro treated cells [142]

normal functioning of the immune system

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8 Conclusion and future perspectives The chronic, relapsing nature of UC and the rising global prevalence of UC, especially in developed nations, necessitate the urgent need for effective therapeutic strategies