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Notably, the cytotoxicity of both ZIO-101 and ATO was cell cycle-dependent with the highest cytotoxicities in the S and G2/M phases and the lowest in the G1 and S phases [115]

At 12 months, the average HRQoL score in the study group was significantly higher than in the controls (5.60 vs 4.37 p=0.027)

Treatments such as CD52 monoclonal antibodies, mesenchymal stem cells, and specific compounds like Oridonin and KGF-2 have demonstrated efficacy in reducing T cell apoptosis and modulating inflammatory pathways, while other approaches focus on directly influencing intestinal epithelial cells to mitigate CD symptoms

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Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults