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However, if saturated fatty acids accumulate in excess in cells, they become toxic and induce the generation of ROS, endoplasmic reticulum stress and NLRP3 inflammasome activation, which are all associated with a pro-inflammatory macrophage phenotype (Legrand-Poels et al., 2014)

The reactivity and functional consequences of nitrosylation at a variety of nucleophilic centers in biological molecules represent another intervention accerssible by GSH therapy

AMSH is an endosome-associated ubiquitin isopeptidase

Melatonin, secreted by the pineal gland in response to darkness, plays a key role in maintaining circadian homeostasis and exhibits broad oncostatic properties 19

The slides were then incubated with horse anti-rabbit IgG (BA1100, Vector) for 30 min at room temperature, followed by the VECTASTAIN Elite ABC-HRP kit, peroxidase (PK6100, Vector) for 30 min at room temperature