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CREB is activated by UVC through a p38/HOG1dependent protein kinase

While NSAIDs impair recovery through gut injury, nutrient depletion, cardiovascular strain, and delayed tissue repair, opioids alter pain through a fundamentally different mechanismsuppressing central pain perception without addressing inflammatory or structural drivers

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Model building The maximal effect (E max ) model built up via non-linear mixed-effect modeling (NONMEM, edition 7, ICON Development Solutions, Ellicott City, MD, United States) was used for analysis