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The cardiac work (Xu et al., Circulation 2023, PMID 37961903) showed pan-ERR agonism via SLU-PP-332 and the related compound SLU-PP-915 ameliorated pressure-overload heart failure in mice without inducing pathological cardiac hypertrophy a relevant safety datapoint for ERR agonism in cardiac tissue, since some classes of metabolic agents do drive maladaptive remodeling

Because the body cannot naturally produce B12, it must be obtained from diet or supplementation, unlike many other vitamins

Movement, light, sound, and other triggers may result in symptoms including brief loss of vision, irritation, difficulty speaking, pain, nausea, and visual abnormalities

Huang QF, Sheng CS, Li Y, Dou Y, Zheng MS, Zhu ZM, et al