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More recently, it is becoming well-recognized that a better understanding of cellular signaling pathways alternation under toxicological insult will benefit the risk assessment and early stage prediction of drug toxicity (Wink et al., 2014, 2017)

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Full improvements may take longer depending on severity and how quickly levels rise

This narrative review elucidates the effects of viral hijack on host cellular machinery during SARS-CoV-2 infection, ensuing detrimental effect(s) of virus-induced HMRD on human metabolism, consequential symptomatic clinical implications, and damage to multiple organ systems