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The hair-growth interest comes from a line of animal research: T4 was shown to increase hair growth in rats and mice by activating hair-follicle stem cells in the bulge region, per PubMed (Philp et al., 2003, DOI), with follow-up work showing faster regrowth in T4-overexpressing mice and slower regrowth in knockout mice via VEGF and P38/ERK/AKT signalling (Gao et al., 2015, DOI)

It is often associated with energy-balance models due to its role in appetite and metabolic pathway research

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study reflected a realistic but difficult patient-enrollment scenarioa minimum of 6 months of symptoms (a mean of almost 19 months) despite previous attempts at all other well-known interventions