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A damaged skin barrier can perpetuate inflammation and oxidative stress, both of which trigger increased melanin production as a protective response

Subcutaneous injection delivers the peptide directly into tissue where it can exert systemic effects

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These cohorts serve as compelling examples of the lack of direct GH counter-regulatory effects on pancreatic -cell insulin secretion, thus implying that circulating insulin exerts its glucose-lowering effects more efficiently in these subjects compared with healthy controls