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Notably, combining GLP-1 receptor agonists with SGLT2 inhibitors synergistically improves glomerular hyperfiltration and proximal tubule sodium reabsorption through complementary mechanisms (Maruyama-Sakurai et al., 2024), though gastrointestinal adverse events such as nausea and vomiting may affect long-term adherence in approximately 20% of patients (Yarlagadda et al., 2023)

However, paclitaxel chemotherapy often leads to peripheral neuropathy which is the most prominent adverse effect that reduces the patients quality of life and demands dose reduction leading to decreased disease curing

Peripheral Neuropathy: Understanding Pins and Needles Sensations Peripheral neuropathy is a key symptom of Vitamin B12 deficiency

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Smoking and alcohol consumption Studies have revealed a significant increase in Hcy levels in smokers compared with non-smokers [2730]