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It is suggested that effective intervention on Hub FRGs is helpful to promote the activation of CD4 + T cells in patients with GC and to improve the efficacy of immunotherapy

For example, enhancing neuronal glucose uptake and utilization or modulating specific metabolic pathways could provide protective effects against metabolic stress and neurodegeneration (Riera and Dillin, 2015)

These are substances your body uses to make NAD on its own

10.1038/s41419-025-07510-6 26 DiniG.CeccarelliS.CeliF

*Correspondence: Hua-you Luo, [email protected] Zhu, [email protected] Xu, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers