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Imbalances in the GSH system can contribute to the development of retinal diseases, such as age-related macular degeneration, glaucoma, diabetic retinopathy, and retinitis pigmentosa (RP)

However, AARS is an exception, which relies on lactate-AMP as an intermediate to directly transfer lactyl group to the lysine residues of target proteins with the assistance of ATP [25, 26] As the most well-studied writer, p300-catalyzed lactylation mainly promotes gene transcription [28,29,30,31,32,33,34,35,36,37,38,39] and maintains normal protein structure and functions [40,41,42,43,44,45]

Canolol treatment restored gastric mucosal antioxidant defenses by significantly increasing the levels of glutathione, CAT, and SOD

Hence, GSH may interact with the epigenome on multiple levels

Debenzylation of 3-PBLG 3-armed poly(l-glutamic acid (3-PLG) nanocarriers were synthesized by using trimethylsilyl iodide (TMSI) to debenzylate 3-PBLG (Fig