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Figure 2 Beyond these hormonal effects, excessive iodine intake has also been linked to thyroid autoimmunity, which has been associated with increased infertility rates, polycystic ovary syndrome, premature ovarian insufficiency and endometriosis (76, 77)

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Recent studies have highlighted that key signaling pathways, including Toll-like receptor/nuclear factor-B (TLR/NF-B), Janus kinase/signal transducer and activator of transcription (JAK/STAT), purinergic P2X7 receptorinflammasome signaling, heat-shock proteinmediated stress responses, and phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) cascades, govern the initiation, amplification, and resolution of ischemic renal injury

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It is recommended to bring water, snacks, sunscreen, a hat and suitable walking shoes, since the terrain is steep and slippery in some parts