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Garte S, Gaspari L, Alexandrie A-K, Ambrosone C, Autrup H, Autrup JL, et al

We found that the IgG forms of C34 and C37 caused VLP aggregation when the molar ratio with VLPs exceeded 25:1 and 120:1, respectively (i.e., the equivalent ratio of Fab to E protein dimer was approximately 0.3:1 and 1.5:1)

A second opinion should clarify the pain type, the likely pain generator, whether the proposed procedure fits the case, and whether a non-surgical or less invasive option should be tried first