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While studying human lung cells, the Salk team discovered that elevated levels of the enzyme acid ceramidase make senescent cells more susceptible to ferroptosis and can pass that vulnerability to neighboring cells

EC50 refers to the concentration of an antibody or an antigen-binding portion thereof or an immunoconjugate described herein, that induces a response, either in an in vitro or an in vivo assay, which is 50% of the maximal response, i.e., halfway between the maximal response and the baseline