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The Mount Sinai Journal of Medicine, New York, 78 (6), 872881

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Glutamate, a key neurotransmitter involved in the pathophysiology of schizophrenia and the regulation of sleep-wake neurobiology, plays a crucial role in mediating the quality of sleep, as evidenced by the correlation between sleep disturbances and glutamate levels in specific brain regions of individuals with schizophrenia

In addition, they are also expressed in the digestive, reproductive and immune system, lungs, heart, kidneys, endothelium of blood vessels and smooth muscles to a lesser extent (Izzo and Sharkey, 2010)