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Ultimately, a successful therapeutic paradigm will likely emerge as an integrated composite system that combines the pharmacological optimization potential of natural products with the microenvironment-remodeling capabilities of cell-based therapies

[DOI] [PMC free article] [PubMed] [Google Scholar] Lloyd E, Somera-Molina K, Van Eldik LJ, Watterson DM, Wainwright MS (2008) Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

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In summary, the therapeutic landscape ranges from readily deployable systemic modulators to highly specific but investigational transporter-targeted approaches