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In early disease, microglia adopt a pro-inflammatory phenotype, releasing interleukin-1, tumor necrosis factor alpha (TNF-), and other mediators that amplify endothelial activation, compromising the inner BRB ( Hyperglycemia-linked pathways Chronic hyperglycemia increases flux through the polyol pathway, where aldose reductase reduces glucose to sorbitol using NADPH ( Lipid remodeling, peroxidation, and ceramides Diabetes substantially alters the retinal lipid landscape, including loss and remodeling of long-chain PUFAs

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4 Phytochemicals that have an inhibitory effect on Cutibacterium acnes Considerable efforts have been made to find plant-derived antimicrobials against C

It reduces hippocampal oxidative stress and glial activation while preventing inflammatory cell infiltration in rats (Ianara Mendona Da et al., 2019)

Acknowledgements This work was supported by the National Natural Science Foundation of China (21521003 and 21432002) and the National Key Research and Development Program of China (2016YFA0501500)