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Confocal microscopy revealed a pronounced nuclear-to-cytoplasmic translocation of HMGB1/2-GFP following Hcy or HTL exposure (Figure 5B), with extracellular fluorescence intensity quantification further confirming increased HMGB1/2 secretion (Figure 5C)

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Finkelstein JD

Harada K, Hwang H, Wang X, Abdelhakeem A, Iwatsuki M, Blum Murphy MA, Maru DM, Weston B, Lee JH, Rogers JE, Thomas I, Shanbhag N, Zhao M, Bhutani MS, Nguyen QN, Swisher SG , Ikoma N, Badgwell BD, Hofstetter WL, Ajani JA

While many treatments offer long-lasting results, maintenance sessions may be required to sustain the effects

The identification of the amino acids in CD44 that are responsible for hyaluronan binding