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Diet-induced obese mice develop peripheral, but not central, resistance to leptin

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Research shows that plasma levels of this peptide decline dramatically with age, dropping from approximately 200 ng/ml at age 20 to around 80 ng/ml by age 60

Firstly, to quantify the glycolytic activity of ILC2s ex-vivo, we analyzed their production of L-lactate, a terminal metabolite produced in the glycolysis pathway, noting that melatonin treatment precipitated a marked decrease in concentration ( Figure 5G )