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In summary, in recent decades, NADs development has undergone significant progress and achieved considerable results

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Specifically, EGFR activation triggers ERK-mediated phosphorylation and nuclear translocation of ACSS2, which binds to KAT2A, functioning as a lactyltransferase to promote H3K14/18la and facilitating Wnt/b-catenin, NF-kB, and PD-L1 expression

This method allows for harvesting large numbers of grafts in a single session but leaves a linear scar in the donor area

Yamanakas discovery represented a pivotal moment in regenerative medicine, as it provided a relatively simple and reproducible method for generating iPSCs